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The low molecular weight peptides (~10 kDa) can cross the blood-brain barrier, theoretically delivering neurotrophic support directly to neurons
Under normal physiological conditions, oxidationreduction activity of Fe 2+ in the form of LIP is maintained at a low concentration (approximately 0.20.5 M) to meet metabolic requirements (Petrat et al., 1999)
Other Solvents: For some more complex, hydrophobic peptides, solvents like 10% acetic acid might be required to get them into solution
Understanding the fundamental role of Intrinsic Factor and Transcobalamin II in B12 abortion, utilisation and recycling required for effective mitochondrial delivery is also vital
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