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Furthermore, in participants with T2D, treatment with the selective long-acting GIP receptor agonist, macupatide, was associated with a larger insulin sensitivity improvement compared with the selective GLP-1 receptor agonist dulaglutide, despite similar body weight reduction, and combination therapy with these agents was associated with additive effects on insulin sensitivity [20]
In its modified form, MT1 is more potent and resistant to breakdown than endogenous -MSH [7]
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