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Management: Rotate sites, use smaller insulin syringes, and keep injection volume low (0.5 mL) Potential for IGF-1 Resistance or Downregulation Using IGF1 LR3 continuously without breaks can desensitize IGF1 receptors , reducing effectiveness over time

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Research into oral GLP-1 RAs aims to overcome these obstacles by developing small molecule agonists that can provide the same therapeutic benefits without the need for injections

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