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In addition to pharmacological therapy, all participants received standardized dietary counseling and were advised to follow a hypocaloric diet providing approximately 1,2001,400 kcal per day for 24 weeks
Glutathione supplementation requires daily consistency for 8-12 weeks before visible skin changes appear
Clinical implications The diagnostic performance of thalamic GSH (AUC = 0.879) in this exploratory analysis suggests it warrants further investigation as a potential candidate diagnostic marker
Some patients describe a dramatic decrease in hunger from the very first dose, whilst others notice more gradual changes over the first week
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