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The foundational pharmacology papers characterize cyclic AMP accumulation and beta-arrestin recruitment at both human receptors in recombinant cell systems, establish the imbalance in favor of the GIP receptor, and report the signaling-bias observation at the GLP-1 receptor

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It could be hypothesized that more advanced disease may be more resistant (or very high-risk groups more non-responsive) to the beneficial effects of GLP-1 receptor agonists on CV outcomes

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