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26), the indole interacts with F324, G325, P439 and L441 present in subpocket B (Fig

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Cell Metabolism (2022) 6

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Evidence: Phase 2 trials (e.g., REINFORCE program) showed up to 15-20% body weight reduction over 32-68 weeks when co-administered with semaglutide, outperforming semaglutide monotherapy (10-15% loss)

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Prefrontal glutamate release into the core of the nucleus accumbens mediates cocaine-induced reinstatement of drug-seeking behavior

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