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In a phase 3 trial (OASIS 4) comparing oral semaglutide 25 mg (the Wegovy pill) to placebo, the most common side effects were: Nausea Vomiting Constipation Indigestion (dyspepsia) Diarrhea Most side effects were mild or moderate and went away without stopping treatment
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Mild bloating or gastrointestinal discomfort
Concurrently, the aberrant accumulation of ectopic lipids, such as palmitic acid, triggers local mitochondrial damage and lipid peroxidation to further accelerate these RCD processes (5)
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