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Clinical trial results In phase 3 trials, average weight loss over 68 weeks was: 20.4% with CagriSema 14.9% with semaglutide alone 11.5% with cagrilintide alone 3% with placebo Side effects were mostly mild to moderate, similar to current GLP-1s
These more motivated patients may exhibit other positive behaviors such as maintaining a healthy diet and engaging in regularexercise, which could provide further protection against fractures
Microglial activation was observed at 10 months, but no neuronal loss was noted
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