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Although in vitro studies have demonstrated that Grx3Fra2 complexes can donate a [2Fe-2S] cluster to Aft2, and genetic studies in yeast support this evidence of a direct FeS transfer to Aft1, studies have not yet made clear whether Grx3-type homodimers directly deliver FeS clusters or iron ions to targets in yeast or human cells
[68] [70] [69] For comparison, valproate was found to be 4- to 46-fold less potent in inhibiting the class I HDACs relative to butyric acid (butyrate)
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