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Contraindications Given the limited safety data, conservative contraindications would include pregnancy or plans to become pregnant, breastfeeding, age under 18, severe liver or kidney disease, and any condition requiring medications with unknown interaction potential
This dose is safe and works well for most adults
Both pills and injections have excellent safety profiles
Because the reaction consumes both nicotinamide and a methyl donor, changes in NNMT expression may influence the availability of metabolites associated with NAD turnover and methylation balance
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