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Alcohol itself can cause gastritis and gastrointestinal irritation, potentially compounding the gastrointestinal side effects of GLP-1 medications
However, it should also be recognized that it may be difficult to definitively demonstrate whether DPP-4 does play a physiologically relevant role in cleaving some endogenous substrates in vivo because it can be difficult to distinguish between the intact substrate and the truncated metabolite (because assays are not specific or sensitive enough) and/or because it may be difficult to obtain appropriate samples (e.g., from synapses [neurotransmitters] or interstitial fluid [paracrine signallers])
Research published in Clinical Immunology explored this further
It works by signaling fullness to the brain and slowing how quickly food leaves the stomach
