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Oxalate is present in many foods such as spinach, chard, nuts, black pepper, poppy seeds, and also occurs as a result of the metabolism of ascorbic acid, and the amino acids glycine, serine, and 4-hydroxyproline as well as metabolism of ethanolamine

Following a conformational alteration, it subsequently gains entry into the brain parenchyma

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For these individuals, even a low-risk cosmetic source should be discussed with a clinician before use