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The expression of the immunoproteasome 5i, which is important for the degradation of oxidized proteins under stressful conditions, was decreased in ibuprofen treated male livers relative to controls whereas it was increased in female mice livers in ibuprofen treated group
The whole process occurs inside melanosomes and begins with the translocation of the enzyme tyrosinase, which catalyzes the oxidation of tyrosine into dihydroxyphenylalanine (DOPA) and subsequently into dopaquinone (DQ) 37 (Fig
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