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Interestingly, all three cytokines elevated in SZ patients in Table 1 (IL-1, IL-6, and IL-8) are regulated via the NF-B pathway
Doses of 3 to 4 mg have been tried in early Phase 1 work but produced disproportionate increases in side effects (edema, arthralgia, glucose intolerance) without additional efficacy
To go back to the car analogy, when both are supported, the engine runs more smoothly and efficiently for the long haul
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