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Ethacraplatin a dual-threat platinum (IV) prodrug is a cisplatin molecule coordinated to two ethacrynic acid ligands which is able to inhibit irreversibly GSTP1-1 enzymatic activity being reduced and cleaved as a consequence of binding (Fig
Moreover, Emir et al
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Numerous studies have demonstrated that several factors contribute to doxorubicin-induced acute cardiotoxicity, with oxidative stress and cell death being the most significant [85, 86]
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