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Because the milligram amount is fixed, a lighter body gets more drug exposure per pound: roughly 22% more at 70 kg and about a third less at 120 kg, compared with a 90 kg reference. The dose still comes from response and tolerability, but a lighter person is running a hotter exposure at the same number on the vial
You dont know if youre getting therapeutic doses or just trace quantities for marketing
Liver disease can disrupt SAM production, SAH disposal and the normal balance between methyl-group supply and demand
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