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Next, to further investigate the role of Trim37 in PGCs in vivo, we first generated Blimp1-T2A-Cre knock-in mice and validated Cre-mediated loxP recombination in gonads using Rainbow mice 29 (Supplementary information, Fig

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An example is copper-dependent enzymes lysly oxidase (cross-links collagen and elastin to rebuild connective tissues), and superoxide dismutase (major antioxidant enzyme to protect against damage/aged cells), with both contributing to collagen formation, antioxidant defenses, and extracellular matrix rebuilding

Toll-like receptor 4 deficiency reduces oxidative stress and macrophage mediated inflammation in hypertensive kidney