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Approximately 30% of participants discontinued their involvement between recruitment and the 6-month follow-up 20

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Among these, we may include (i) the physicochemical conditions of operation for maximum active enzyme concentration per unit of cell (protein synthesis, activity and/or stability), such as pH, temperature, osmolarity and the presence of activators/inhibitors, (ii) the concentration of both the catalyst and the substrate being used, (iii) the biocatalytic environment (i.e