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The infusion skips that stage and delivers the full dose directly into the bloodstream
Within smooth muscle cells (SMC), NO reacts with the heme moiety of a soluble guanylate cyclase (sGC), resulting in activation of the latter and a consequent elevation of intracellular levels of cGMP
Close monitoring of kidney function, appropriate dose adjustments, or replacement with a suitable alternative may be required based on the clinical condition of the patient
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