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A 28.3% reduction in body weight averaging 70.3 pounds lost over 80 weeks is the headline number from retatrutides TRIUMPH-1 phase 3 trial, and it lands at a moment when the obesity pharmacology field thought it had already seen its ceiling

We acknowledge that only male mice were used in this study to avoid variability from the female estrous cycle, and therefore sex-specific differences could not be evaluated

In a phase 2 trial published in The New England Journal of Medicine , retatrutide produced substantial weight loss in adults with obesity or overweight over 48 weeks, with the highest-dose groups achieving reductions that reached up to 24.2%