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The compound is not classified as a controlled substance, but selling it as a health product violates Canadian law

Work from Marko et al demonstrated that treatment of human neuronal cells with post-exercise serum, albeit aerobic, was associated with decreased expression of amyloid processing enzyme -secretase linked to production of A and increased expression of non-amyloidogenic enzyme -secretase, producing the soluble amyloid proteins that have not been implicated in neurodegeneration (Marko et al., 2022)

ZNRF proteins constitute a family of presynaptic E3 ubiquitin ligases

However, others using specific oral preparations reported peripheral edema, gastrointestinal symptoms, headache, fever, and infections (32) (33)