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c , d , Representative confocal images of ATG7 knockout (KO) HeLa cells expressing mito-GFP (mitochondria) and LAMP1-mCherry (lysosomes) under normoxia (N) or hypoxia/reoxygenation (HR) and immunostained with antibodies against DRP1 (c), and the number of DRP1 puncta localized to lysosomes per ATG7 KO cell under normoxia (N) or hypoxia/reoxygenation (HR) (d, n = 60 cells, three experiments)

Riederer P, Sofic E, Rausch WD, Schmidt B, Reynolds GP, et al

Additionally, ER stress can induce AMPK activation via increased cytosolic Ca 2+ levels, providing an alternative route for autophagy initiation (Mizushima and Komatsu, 2011)