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The first meta-analysis, performed in 2007 to overcome the limits of small case-control cohorts, included 1.129 MDS and 1.489 control mothers, reported borderline results, and could neither confirm nor exclude a contribution for this polymorphism (Zintzaras, 2007), but all the subsequent meta-analyses, performed in recent years following the increasing number of available research papers, confirmed association with the maternal risk of birth of a child with DS (Table 2)

doi: 10.1016/j.pbiomolbio.2025.05.003 239 BonnetSArcherSLAllalunis-TurnerJHaromyABeaulieuCThompsonRet al

Production of HGH typically remains sufficient until our early 20s, then declines with age

Insulin sensitivity improvements build gradually