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These models have shown that cells with A8344G mutation exhibit reduced oxygen consumption, increased ROS production, altered growth, and fragmented mitochondria indicating mitochondrial dysfunction in MERRF syndrome ( in vitro modeling of this disease

Chappidi et al., 2024)

GHK-Cu stimulates collagen I, III, and elastin synthesis in fibroblasts Promotes decorin and glycosaminoglycan production for matrix integrity Attracts immune cells and promotes wound debridement and repair GHK-Cu may prevent oxidative stress in skin by regulating copper and modifying expression of numerous antioxidant genes2012Gene Expression Gene expression analysis reveals GHK-Cu upregulates antioxidant genes and downregulates pro-inflammatory genes, suggesting a protective role against oxidative stress and UV damage in skin

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