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Metformin and GLP-1 medications target weight loss and glucose management through different biological pathways, making their combination a clinically sound strategy for many patients

GIP Receptor Activation Glucose-dependent insulinotropic polypeptide receptors play crucial roles in nutrient metabolism and fat tissue regulation

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Strong preclinical coverage: improved insulin sensitivity in aged and high-fat-fed mice (Lee et al., Cell Metabolism 2015) and roughly doubled treadmill running time in old mice (Reynolds et al., Nature Communications 2021)