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These results indicated that GSH and -EC were more stable at 25 C than at 37 C, suggesting that higher productivity of -EC may be obtained at 25 C than at 37 C, despite the reduced reaction rate

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Also, the adverse cardiovascular safety in clinical trials before 2008 was evaluated based on populations that were not necessarily at high risk of cardiovascular disease and the follow-up duration was relatively short (usually less than 12 months)

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