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Reduced oxygenation shows up as paleness, a sallow or washed-out complexion, and slower wound healing

Primarily studied in rodent models of cognitive decline

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3.3 Changes in serum cobalamin by supplementation route and dosage Across 35 comparisons, the mean percentage increase in serum cobalamin following supplementation was approximately 293%, confirming the overall effectiveness of vitamin B12 interventions (Supplementary Table S4)