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Unexpectedly, SNPs related to HIF/EPO pathway genes ( EGLN1 , EGLN2 , EGLN3 , EPO , EPOR , HIF1A , PTEN , and VHL ) have failed to establish a definitive correlation with CMS susceptibility among male Peruvian Quechua natives, potentially due to flawed grouping: non-CMS controls lacked strict criteria (non-CMS: individuals with a CMS score 3000 m, prophylaxis should be strongly considered
