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Moreover, in subjects with diabetes who were at high risk of cardiovascular events, treatment with GLP-1R agonists based on the structure of endogenous GLP-1, namely liraglutide, semaglutide, albiglutide, and dulaglutide, has demonstrated reductions in major adverse cardiovascular events (MACEs) that appear to be unrelated to the glycemic effects of these agents (1316)
reference.medscape.com
This decline happens naturally with age, but obesity accelerates the process significantly
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