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While routine vitamin B12 monitoring is not specifically mandated in tirzepatide prescribing information, clinical judgment should guide individualized screening strategies based on patient risk factors and clinical presentation
Its pharmacology is relatively narrow: it stimulates lipolysis through beta-3 adrenergic receptor pathways in adipose tissue and may inhibit lipogenesis [1]
Taken together, all these issues make less weight loss an expected finding in SELECT, compared with STEP 1
Br J Psychiatry
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