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Furthermore, liraglutide treatment for 10 days in obese T2DM patients attenuated insula and putamen fMRI responses to food pictures in fasted and post-meal conditions, compared with insulin glargine injection [42]
On one hand, it can degrade intestinal mucin glycoproteins by enzymes (such as glycoside hydrolases, proteases, sulfatases, and sialidases) to produce SCFAs, acetates, propionates, and 1,2-propanediol, as well as succinates and sulfates, promoting mucin turnover and thickening, thereby enhancing intestinal barrier function and reducing the permeability of gut microbiota products
Obstet Gynecol (New York 1953)
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Other factors may also impact differences such as age, source of mice, animal facility temperature, diet, and the microbiome which have demonstrated impacts on both obesity and cancer 29
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