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Many patients report that the transition off semaglutide feels abrupt, even though the pharmacological withdrawal is gradual
doi: 10.1016/j.nbd.2016.01.020 303 WooT.-G.YoonM.-H.KangS.-M.ParkS.ChoJ.-H.HwangY
These results indicate that the increased amount of non-12-OH FXR-antagonistic BAs consequent to the decrease in CYP8B1 expression after T3 treatment potentiates GLP-1 production by deactivating the intestinal FXR, thereby improving glucose homeostasis via the augmentation of insulin secretion
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