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Sections were incubated for 15 minutes at ambient temperate with a polyclonal rabbit anti-human GLP-1R antibody (ab39072, Abcam, Cambridge, UK) at a dilution of 1:1,000, using a biotin-free polymeric horseradish peroxidase linker antibody conjugate system

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In the SURMOUNT-1 clinical trial, gastrointestinal adverse events were the most commonly reported side effects across all dose groups

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