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(2017) The glutamate/cystine xCT antiporter antagonizes glutamine metabolism and reduces nutrient flexibility, Nat

As a result, the brain consumes a substantial amount of energy to sustain its physiological activities

I have been self injecting for several years as I was taken off B12 injections and told I didnt need them, however my symptoms came back and the only thing that makes me feel better is B12

Mechanistic experiments using the PI3K inhibitor wortmannin demonstrated that PI3K/AKT signaling is required for the anti-inflammatory and anti-apoptotic effects, identifying the brain AngIV/PI3K/AKT axis as the proximate mechanism in this model