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Another study analyzing the hepatic safety of systemic psoriasis treatments reported no significant hepatotoxic effects with apremilast compared to methotrexate and acitretin, which are well-documented for their potential liver toxicity (Munera-Campos et al
This effect was mediated via adenylate cyclase (AC) / PKA signaling pathway, as it was abolished by the GLP-1R inhibitor exendin-9, or by PKA inhibitors SQ22536 and H89 [58]
Golan A et al
doi:10.1021/bi800529f
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