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While growth and sexual development in WT cells faltered early with lower levels of erastin treatment, parasites grown in SQLE -KO cells were much more resistant to erastin (Fig 4D)

However, amino acid analogs are unsuitable for clinical use due to their low affinity, lack of specificity, and toxicity 87

GLP- 1's anti-apoptotic and proliferative effects are also mediated by the PI3 K/Akt axis through the transactivation of the epidermal growth factor receptor (EGFR), which is connected to GLP- 1 receptor through c-Src activation and the generation of endogenous EGF like ligands [59]

Despite its importance in crop improvement, the specific dynamics of compartmentalised NADP redox state have been difficult to assess 36,37,38