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A Phase Ib Study of JS001, a Humanized IgG4 mAb Against Programmed Death-1 (PD-1) Combination With Axitinib in Patients With Metastatic Mucosal Melanoma
Development of kidney disease is associated with the enzyme myeloperoxidase (MPO), abundant in neutrophils catalyzing the transformation of hydrogen peroxide (H 2 O 2 ) to hypochlorous acid (HOCl), a powerful oxidizing cytotoxic agent, according to the reaction HOCl has been found to be responsible for renal dysfunction among obese children
The compound was developed to engage with the melanocortin receptors impacting melanin synthesis
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