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Cancer cells use more glutamine than healthy cells
The sequence is proline-rich, with three consecutive prolines followed by a fourth at position eight, and that conformationally constrained backbone is the usual structural explanation offered for the resistance
Here are the visual and physical cues that scream time to toss this: Visual inspection checklist: Cloudiness or particles floating in the solution Color changes (these should be clear and colorless) Clumping or gel-like consistency Crystals forming in the liquid Physical signs: The pen mechanism isnt working smoothly Unusual resistance when injecting The medication feels warm when it should be cool If you notice any of these signs, dont risk it
its first-in-human pharmacokinetics by Urva and colleagues (The Lancet, 2022)
