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Rarely, it can cause muscle weakness in people with uremia and seizures in those with or without a history of seizure disorders

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During wound healing, it can be removed from existing extracellular proteins by proteolysis and used as a chemical attractant for inflammatory and endothelial cells It can increase the production of messenger RNA in collagen, elastin, proteoglycans and glycosaminoglycans in fibroblasts

The 2.4 mg weekly maintenance dose is where the phase 3 monotherapy trials showed the strongest results, with an average body weight reduction of 11.8% over 68 weeks