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Clinical Studies 14.1 Heart Failure The Randomized Aldactone Evaluation Study (RALES) was a placebo-controlled, double-blind study of the effect of spironolactone on mortality in patients with highly symptomatic heart failure and reduced ejection fraction

Mechanism of Action Each receptor does something different: GLP-1 suppresses appetite and slows digestion, GIP improves insulin sensitivity and fat metabolism, and glucagon increases energy expenditure

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I schemic stroke/transient ischemic attack : 7.6% vs