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Cardiovascular outcomes trials have demonstrated reduced rates of major adverse cardiovascular events in high-risk patients treated with liraglutide (LEADER trial) and semaglutide (SUSTAIN-6 trial)
However, these interventions do not effectively prevent the progression of DKD and are associated with side effects, such as hyperkalemia, hypoglycemia, and urinary tract infections
The unresponsiveness to psychotherapy, in contrast to past treatment experience, also suggests there may be some new contributing factors
Semaglutide's patent will also expire in 2026
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