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( c ) Energy expenditure recorded in metabolic cages (with ANCOVA using BW as covariate) and ( d ) corresponding ambulatory activity ( c , d : CON VEH n = 7, CON acyl-GIP n = 7, Gipr AP-KO n = 8 and Gipr AP-KO acyl GIP n = 8)

Instead, it lowers the ferroptotic threshold of recipient cells by destabilizing the membrane localization of solute carrier family 7 member 11 (SLC7A11), the light-chain subunit of system xc , responsible for cystine uptake, through CD44-dependent signaling