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Treatment of rats with roridin E caused minimal toxicity on the hepatic and renal tissue, however, co administration of linoleic acid with roridin E resulted in increase toxicity due to increased incorporation to the cell membrane or inhibit its biotransformation [159]

Licensed UK alternatives for weight management include Wegovy (semaglutide 2.4 mg) under NICE TA875, and Mounjaro (tirzepatide) for eligible patients with type 2 diabetes