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Age-related changes in kidney and liver function may affect drug metabolism and clearance, potentially increasing the risk of adverse effects
Neither showed any effect on the primary endpoint, the Clinical Dementia Rating-Sum of Boxes at 104 weeks, nor on secondary cognitive and functional scales, and a pooled analysis found no delay in progression from mild cognitive impairment to dementia (hazard ratio 0.96) [1]
Bottom Line Yes, some patients report irritability while using GLP-1 medications No, this is not common and not clearly a direct drug effect Most cases are related to under-fueling, blood sugar changes, sleep disruption, or reward pathway shifts With proper guidance and monitoring, GLP-1 medications remain safe and effective for most people If mood changes occur, they deserve attentionnot panic, but thoughtful evaluation
