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[7] [8] Diversity [edit] Two classes of thioredoxin reductase have evolved independently from a shared ancestor of the FAD/NAD(P)-binding domain superfamily (IPR036188): A high molecular weight (MW = ~55,000) type containing a selenocysteine residue in its active site has been identified in higher eukaryotes including humans

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Constant, non-pulsatile GH rise (as occurs with synthetic GH use) can lead to receptor desensitization, where target tissues become less responsive to growth hormone over time