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In clinical trials, diarrhea is a common side effect, occurring in approximately 30% of patients taking Wegovy (semaglutide 2.4 mg) and 19-23% of patients taking Zepbound (tirzepatide), according to FDA prescribing information
Key safety concerns include potential insulin sensitivity effects linked to certain CLA isomers and the possibility that L-carnitine increases TMAO via gut bacteria in some people which has been associated with cardiovascular risk in observational studies
Besides NF-B, NADPH oxidase can also be activated by TNF- in the endothelial and vascular smooth muscle cells (13)
Trends Pharm Sci
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