Simultaneously, Novo Nordisks SELECT trial confirmed a 20% reduction in major adverse cardiac events with semaglutide, expanding prescriber confidence and unlocking reimbursement across high-risk populations
Patients need to understand what each component does, why it was prescribed, and how to manage the different side effect profiles
Before we can even begin to talk about skin, we have to understand the compound itself
What they found (summary): MC1R: melanogenesis, pigmentation, anti-inflammation MC2R: ACTH receptor in the adrenals (Melanotan II does not act) MC3R: energy, cardiovascular function, anti-inflammation MC4R: appetite (central control), sexual function, autonomic regulation MC5R: exocrine glands (sebaceous, lacrimal, salivary) Mutations in MC4R are the most common monogenic cause of obesity in humans Why it matters: Cones review article is the reference article for all of melanocortin pharmacology