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Numbing creams or ice packs applied five minutes before injection can further reduce sensitivity in individuals prone to injection anxiety, though most patients find these unnecessary after their first or second dose

Many preclinical studies have demonstrated that the expression of key enzymes for GSH synthesis (GCL, SLC7A11, GS) and GSSG reduction-related enzymes (G6PD, NADPH, and GR) is downregulated in myocardium exposed to pathological factors [40, 43,44,45,46,47,48,49,50]

A study found that liraglutide, a specific GLP-1RA, exhibited analgesic effects in animals by reducing inflammation in joint tissues