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HES (for 10 days) to CIPN rats significantly reduced PTX-induced increases in MDA, NF-B, IL-1, TNF-, COX-2, nNOS, JAK2, STAT3, and GFAP levels with neuropathic pain and alleviated endoplasmic reticulum stress (ERS) [133]
Many patients find it helpful to tie their injection day to a regular habitinjecting every Sunday evening with dinner, for instanceso the ritual becomes automatic
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This improves energy levels and reduces fatigue
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