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Oxidative stress (OxS)/cellular damage Oxidative stress (OxS) is a nonspecific pathophysiological condition that reflects a redox imbalance between increased production of ROS (free radicals) and the inability of antioxidant defenses to neutralize the reactive intermediates or to repair the ensuing damage 179,180

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Eligibility Criteria Eligibility criteria were established according to the PopulationConceptContext (PCC) framework recommended by the JBI, which is particularly appropriate for mapping broad evidence bases

This study suggests that because the drugs tackle the drivers (plaques and tangles), they should be tested in earlier stages of the disease, years before memory loss actually starts